Drug Interactions of Nicotex-2mg Chewing Gum: Nicotine increases the haemodynamic and AV blocking effects of adenosine. Monitor for treatment-emergent hypertension in patients treated with combination of nicotine patch and bupropion. Smoking cessation may increase response to various drugs e.g. theophylline, imipramine, oxazepam, pentazocine, some β-blockers; monitor for increased toxicity.
Contraindications of Nicotex-2mg Chewing Gum: Nonsmokers, children and occasional smokers. Recent cerebrovascular accident, acute MI, unstable or worsening angina pectoris, severe cardiac arrhythmias, active temporomandibular joint disease (gum).
Mechanism of Action of Nicotex-2mg Chewing Gum: Nicotine is a potent ganglionic and CNS stimulant. It paralyses all autonomic ganglia after stimulation of the respiratory system (a central effect of small doses). Larger doses produce medullary-type convulsions then paralysis. The actions of nicotine are mediated via nicotine-specific receptors. Onset: Formulation specific.
Duration: Formulation specific. Distribution: Crosses the placenta and present in breast milk. Metabolism: Metabolised principally in the liver via oxidation. Excretion: Excreted in the urine (10-20% as unchanged drug). Excretion is pH dependant with increased excretion in acidic urine.
Special Precautions for Nicotex-2mg Chewing Gum: Use with caution in oropharyngeal inflammation and in patients with cerebrovascular disease, heart failure and renal impairment. History of oesophagitis, peptic ulcer, CV disease, hyperthyroidism, hepatic dysfunction; myasthenia gravis; DM (monitor blood glucose concentrations); pregnancy, lactation; peripheral vascular disease; skin disease (should not be applied on broken skin).